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    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

    Mehabaw G Derebe et al.
    Serum amyloid A proteins bind retinol with nanomolar affinity, and do so by forming oligomers that create a hydrophobic pocket that shields retinol from the aqueous environment.
    1. Immunology and Inflammation

    Yolk-sac-derived macrophages progressively expand in the mouse kidney with age

    Shintaro Ide et al.
    A combination of genetic fate-mapping and parabiotic experiments reveals the chronological expansion of yolk-sac-derived renal tissue-resident macrophages with age by cellular proliferation and recruitment from circulating progenitors.
    1. Developmental Biology

    An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones

    Chenhui Wang, Allan C Spradling
    Drosophila renal stem cells are exceptional in abundance, require induction to produce a single cell type, principal cells, and mitigate damage during adulthood associated with external stresses.
    1. Cancer Biology

    R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

    Jeroen Overman et al.
    Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
    1. Immunology and Inflammation

    Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

    Yasunobu Arima et al.
    A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.
    1. Immunology and Inflammation

    Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

    Jakob Malsy et al.
    Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Biochemistry and Chemical Biology

    Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

    Rima S Chakrabarti et al.
    Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby et al.
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih et al.
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.