1,195 results found
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Immunology and Inflammation
    2. Neuroscience

    Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

    Wenxin Ma et al.
    TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.
    1. Neuroscience

    Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti et al.
    Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
    1. Immunology and Inflammation

    Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

    Jakob Malsy et al.
    Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.
    1. Cell Biology

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo et al.
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

    Toshihide Kurihara et al.
    Mouse models in which hypoxia can be genetically triggered in retinal pigmented epithelial cells show that hypoxia-induced metabolic stress alone can lead to photoreceptor atrophy/dysfunction.
    1. Developmental Biology

    LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus

    Qinbo Zhou et al.
    lncEGFL7OS is a lncRNA located at the EGFL7/miR-126 locus that is critical for angiogenesis in humans.
    1. Neuroscience

    Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

    Ting Zhang et al.
    The important role of serine biosynthesis in Müller cells may explain why the macula is so much more prone to developing disease than the rest of the retina.
    1. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

    Bo O Zhou et al.
    Normal hematopoietic stem and progenitor cells slow the regeneration of their niche after injury to minimize leakage from the niche vasculature.
    1. Cell Biology

    Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

    Ross O Smith et al.
    Pathological vessel leakage in mouse retinopathy models depends on VE-cadherin Y685 phosphorylation status, which in turn is regulated by a signaling cascade originating with VEGFR2 Y949 phosphorylation.

Refine your results by:

Type
Research categories