Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.
Existing artificial retinas produce distorted and imprecise activation of the visual system, but reverse engineering promises to refine the induced activation patterns.
Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
Sarvenaz Sarabipour, Kurt Ballmer-Hofer, Kalina Hristova
A receptor for vascular endothelial growth factor forms dimers in the absence of its ligand, and ligand-binding leads to structural changes that result in increased kinase phosphorylation.
Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21st century.
Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
Elizabeth R Morris, Heather Grey ... Julia M Richardson
Structural and biochemical analyses of a eukaryotic DNA transpososome in the integration step reveal how mariner/Tc1 transposons are selectively integrated into a TA target sequence.
Experimental analysis of SLC38A5 (solute carrier family 38 member 5) in mouse models and cell culture reveals its novel role as a metabolic regulator of retinal angiogenesis by controlling nutrient uptake and homeostasis in blood vessel endothelium.
