4,655 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

    Sarah Latty et al.
    The strength of Toll-like receptor signalling depends on the number and size of MyDDosomes formed as well as on how quickly these structures assemble.
    1. Neuroscience

    A kinase-dependent feedforward loop affects CREBB stability and long term memory formation

    Pei-Tseng Lee et al.
    Through an image and behavioral screen based on MiMIC technology, we identified a novel kinase, CG11221 renamed Meng-Po (MP), and showed that flies that lack MP in mushroom bodies can learn but cannot remember as MP is required for the protein stability of CREBB.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

    Shrestha Ghosh et al.
    The dramatic extension of lifespan in Sirt6-deficient mice by Trp53 haploinsufficiency suggests that SIRT6 has distinct biological function from SIRT1 in regulating p53 activity and preventing cells from senescence/apoptosis.
    1. Developmental Biology and Stem Cells

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Cell Biology

    GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

    Marina Besprozvannaya et al.
    Functionally distinct ER-PM domains in human cells are defined by conserved GRAM domain containing proteins.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita et al.
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Computational and Systems Biology
    2. Biochemistry and Chemical Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.

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