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    1. Developmental Biology
    2. Evolutionary Biology

    Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

    Colton M Unger et al.
    Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
    1. Cell Biology

    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

    Stéphanie Torrino et al.
    UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
    1. Medicine

    Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

    Salwa Naushin et al.
    Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.
    1. Genetics and Genomics
    2. Neuroscience

    Propensity for somatic expansion increases over the course of life in Huntington disease

    Radhia Kacher et al.
    Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
    1. Neuroscience

    Permeabilization-free en bloc immunohistochemistry for correlative microscopy

    Kara A Fulton, Kevin L Briggman
    Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.
    1. Epidemiology and Global Health

    Sex differences in biological aging with a focus on human studies

    Sara Hägg, Juulia Jylhävä
    Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
    1. Neuroscience

    Fully autonomous mouse behavioral and optogenetic experiments in home-cage

    Yaoyao Hao et al.
    A fully automated workflow for high-throughput mouse behavioral and optogenetic experiments in homecage reveals involvement of brain regions in tactile decision-making.
    1. Physics of Living Systems

    Optimal evolutionary decision-making to store immune memory

    Oskar H Schnaack, Armita Nourmohammad
    Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
    1. Cell Biology
    2. Physics of Living Systems

    How cells determine the number of polarity sites

    Jian-geng Chiou et al.
    Minimal essential features of Rho GTPase systems are elucidated that regulate the number of distinct domains developed by a cell’s polarity machinery, which in turn governs cell shape.
    1. Structural Biology and Molecular Biophysics

    Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

    Rahul Chadda et al.
    Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.