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    1. Cell Biology
    2. Neuroscience

    A genetic toolkit for tagging intronic MiMIC containing genes

    Sonal Nagarkar-Jaiswal et al.
    Building on previous work (Nagarkar-Jaiswal et al., 2015), we report an elegant genetic strategy for endogenous tagging of MiMIC containing genes.
    1. Structural Biology and Molecular Biophysics

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera et al.
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.
    1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll et al.
    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

    Matthew A Churgin et al.
    The WorMotel, a novel microfabricated device for automated longitudinal imaging of aging in large numbers of Caenorhabditis elegans, reveals that long and short lived strains vary in their behavioral decline during aging in a similar way to the long and short lived individuals in a wild type population.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis

    Xiangsong Chen et al.
    Genetic and biochemical studies reveal how a histone deacetylase acts together with other chromatin regulators to promote the onset of plant aging.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin

    Alexandria N Miller et al.
    Cryo-EM structures of the gating cycle of bestrophin reveal the molecular underpinnings of activation and inactivation gating in this calcium-activated chloride channel and reveal a surprisingly wide pore.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

    Tobias Brandt et al.
    Respiratory activity and inner membrane organisation of mitochondria from Drosophila melanogaster break down during ageing, but mouse heart mitochondria appear to be protected against age-related damage.
    1. Cell Biology
    2. Developmental Biology

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Cell Biology

    Time line of redox events in aging postmitotic cells

    Nicolas Brandes et al.
    A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.
    1. Structural Biology and Molecular Biophysics

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong et al.
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.