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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

    Kiersten A Henderson et al.
    Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
    1. Cell Biology

    Time line of redox events in aging postmitotic cells

    Nicolas Brandes et al.
    A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.
    1. Biophysics and Structural Biology

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong et al.
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

    Tobias Brandt et al.
    Respiratory activity and inner membrane organisation of mitochondria from Drosophila melanogaster break down during ageing, but mouse heart mitochondria appear to be protected against age-related damage.
    1. Neuroscience

    A corticostriatal deficit promotes temporal distortion of automatic action in ageing

    Miriam Matamales et al.
    Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.
    1. Cell Biology

    RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

    Dianrong Li et al.
    Necroptosis triggers organ-specific, age-associated deterioration of male reproductive system.
    1. Biophysics and Structural Biology
    2. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey et al.
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Neuroscience

    Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans

    Sarah G Leinwand et al.
    Neurotransmission pathways from primary to secondary neurons encode odor and underlie age-related sensory behavioral declines.
    1. Biochemistry
    2. Biophysics and Structural Biology

    The gating cycle of a K+ channel at atomic resolution

    Luis G Cuello et al.
    X-ray crystallographic studies have completed the first atomic resolution description of the kinetic cycle of a potassium channel's pore domain.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Loss of foxo rescues stem cell aging in Drosophila germ line

    Filippo Artoni et al.
    Loss of foxo rescues age-related defects in stem cell-mediated regeneration post-injury.