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    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

    Laura J Wagstaff et al.
    In vivo experiments on transgenic mice, and cell culture studies, establish Schwann cell c-Jun as a central regulator of peripheral nerve repair, and repair failure, during aging and chronic denervation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

    Minxian Qian et al.
    The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
    1. Neuroscience

    Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

    Xiaoli Zhang et al.
    Tricyclic antidepressants activate lysosomal two-pore Na+ channels in a voltage-dependent manner.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural determinants of voltage-gating properties in calcium channels

    Monica L Fern√°ndez-Quintero et al.
    Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.
    1. Computational and Systems Biology
    2. Ecology

    Combining agent-based, trait-based and demographic approaches to model coral-community dynamics

    Bruno Sylvain Carturan et al.
    A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey et al.
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Loss of foxo rescues stem cell aging in Drosophila germ line

    Filippo Artoni et al.
    Loss of foxo rescues age-related defects in stem cell-mediated regeneration post-injury.
    1. Ecology
    2. Epidemiology and Global Health

    Personality links with lifespan in chimpanzees

    Drew M Altschul et al.
    Among captive chimpanzees, higher agreeableness males and higher openness females survive longer.
    1. Developmental Biology
    2. Genetics and Genomics

    Epigenetic age-predictor for mice based on three CpG sites

    Yang Han et al.
    Site-specific DNA methylation analysis at three CG dinucleotides by pyrosequencing provides a reliable measure for epigenetic aging of mice.