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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease

    Trevor Fisher, Mehaben Patel ... Helene Baribault
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Computational and Systems Biology

    Discovering Root Causal Genes with High Throughput Perturbations

    Eric V Strobl, Eric R Gamazon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics

    Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

    Xiuling Cao, Xiang Wu ... Beidong Liu
    Membrane lipids are involved in the maturation and cytotoxicity of Parkinson's synphilin-1 inclusion bodies.
    1. Genetics and Genomics

    Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice

    Minsoo Noh, Xiangguo Che ... Sihoon Lee
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Medicine
    2. Microbiology and Infectious Disease

    HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

    Ning Song, Hang Gao ... Wenlong Zhang
    Gut microbiota from young mice can alleviate gout and hyperuricemia in aged mice, further revealing that the metabolic product butyrate derived from the gut microbiota exerts similar therapeutic effects.
    1. Genetics and Genomics

    Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies

    Jorge Blanco Mendana, Margaret Donovan ... Daryl M Gohl
    A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.
    1. Neuroscience

    Rate of brain aging associates with future executive function in Asian children and older adults

    Susan F Cheng, Wan Lin Yue ... Juan Helen Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    DNA/polysome phase separation and cell width confinement couple nucleoid segregation to cell growth in Escherichia coli

    Alexandros Papagiannakis, Qiwei Yu ... Christine Jacobs-Wagner
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer’s Disease

    Lena Kallweit, Eric D Hamlett ... Scott Horowitz
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
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