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    1. Neuroscience

    A corticostriatal deficit promotes temporal distortion of automatic action in ageing

    Miriam Matamales et al.
    Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans

    Chaolie Huang et al.
    Age-dependent protein aggregation closely resembles protein aggregation associated with neurodegenerative diseases and other amyloidoses, and initiates early functional decline in different tissues.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Loss of foxo rescues stem cell aging in Drosophila germ line

    Filippo Artoni et al.
    Loss of foxo rescues age-related defects in stem cell-mediated regeneration post-injury.
    1. Stem Cells and Regenerative Medicine

    Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

    Petter Säwen et al.
    Using a lineage tracing model, it is demonstrated that adult murine hematopoiesis is contingent on the continuous output from HSCs, with quantitative contributions that are dependent on lineage-type and age.
    1. Neuroscience

    Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila

    Ashiq Hussain et al.
    Drosophila genetics and behavior reveal that oxidative stress induced axonal degeneration in a single class of neurons drives the functional decline of an entire neural network and the behavior it controls.
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan et al.
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

    Minxian Qian et al.
    The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
    1. Chromosomes and Gene Expression

    Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

    Cristina Cruz et al.
    A widely studied chromatin modification associated with gene promoters is important for proper gene expression across organismal lifetime.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromatin accessibility dynamics across C. elegans development and ageing

    Jürgen Jänes et al.
    Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.