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A widely studied chromatin modification associated with gene promoters is important for proper gene expression across organismal lifetime.

mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.

Damage and repair for both aging mice and humans declined with age, exhibited very long timescales that varied across health attributes, and were differently affected by interventions.

The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.

Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.

Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.

A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.

Iterative immunostaining using 4i enables detailed characterization of complex mouse and human tissues.

Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.

Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.