Structural and biophysical studies detail how Neisseria LbpB interacts with human lactoferrin for iron piracy and provides insight for how LbpB interacts with the antimicrobial peptide lactoferricin.
Thijs L van der Plas, Jérôme Tubiana ... Georges Debrégeas
A data-driven network model offers an interpretable and physiologically sound description of the whole-brain spontaneous neural activity of zebrafish larvae.
Sergio A Muñoz-Gómez, Sebastian Hess ... Andrew J Roger
Diverse sophisticated phylogenetic analyses update the phylogeny of the Alphaproteobacteria and show that the parasitic Holosporales is a derived group within the Rhodospirillales order which comprises primarily free-living alphaproteobacteria.
Hedgehog leads to Smoothened accumulation by favoring its recycling and high Hedgehog levels promote a basolateral enrichment of Smoothened via its phosphorylation by the protein kinase Fused.
A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.
Elizabeth V Wasmuth, John C Zinder ... Christopher D Lima
The nuclear exosome cofactors Mpp6 and Rrp47 can stimulate exoribonuclease activities of the nuclear RNA exosome and recruit the Mtr4 helicase to promote helicase dependent RNA decay.
Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
Nathaniel R Braffman, Terry B Ruskoski ... Emily P Balskus
The X-ray crystal structure of the unusual carbon–carbon bond-forming biosynthetic enzyme CylK reveals a unique biochemical strategy for selective alkyl halide activation and substitution.
