Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
Charles AR Cotton, Iria Bernhardsgrütter ... Arren Bar-Even
Upon deletion of threonine deaminases, biosynthesis of isoleucine is rescued by two promiscuous reactions, one emerges under aerobic conditions and the other is naturally active under anaerobic conditions.
Qiaochu Li, Daniel-Cosmin Marcu ... Karl Emanuel Busch
Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.
The regulatory role of thousands of upstream open-reading frames were measured and used to determine the relative influences of sequence, structural, and positional features on translation regulation and nonsense-mediated decay.
Didac Vidal-Pineiro, Yunpeng Wang ... Anders Fjell
Longitudinal neuroimaging models reveal that cross-sectional indices of brain age do not significantly relate to ongoing brain change, that is, brain aging, but to lifelong, stable variations in brain structure emerging in early life.
Martin Wohlwend, Pirkka-Pekka Laurila ... Johan Auwerx
CERS1 reduction in aging skeletal muscle contributes to impaired muscle function, myogenesis and increases inflammation and fibrosis, highlighting the significance of very long chain ceramides in age-related muscle homeostasis.
Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Oliver Robinson, ChungHo E Lau ... Martine Vrijheid
Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.
The BNT162b2 mRNA COVID-19 vaccine is highly effective at generating immune responses in people over the age of 80 years and provides good cross neutralization of the P.1 gamma variant of concern.
