2,667 results found
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu, Anastasia Chrysidou ... Esther Kuehn
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Neuroscience

    De novo learning versus adaptation of continuous control in a manual tracking task

    Christopher S Yang, Noah J Cowan, Adrian M Haith
    Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
    1. Neuroscience

    The influence of task outcome on implicit motor learning

    Hyosub E Kim, Darius E Parvin, Richard B Ivry
    During a sensorimotor perturbation, task outcome may serve as a gain on implicit adaptation or provide a distinct error signal for a second, independent implicit learning process.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

    Ignacio Izeddin, Vincent Récamier ... Xavier Darzacq
    While the transcription factor c-Myc explores the space in the nucleus in an unrestricted manner, the elongation factor P-TEFb's sampling of the nucleus is constrained to a complex domain with fractal characteristics.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Cell Biology
    2. Physics of Living Systems

    Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status

    Fanny Momboisse, Giacomo Nardi ... Anne Brelot
    Combining particle tracking in living cells with statistical analysis demonstrates how the oligomeric organization of cell surface receptor influences their function, a necessary step in the development of drugs targeting specific receptor conformation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A compartmentalized signaling network mediates crossover control in meiosis

    Liangyu Zhang, Simone Köhler ... Abby F Dernburg
    A regulatory circuit that localizes to the synaptonemal complex, a liquid crystalline compartment between chromosomes, ensures crossing-over while limiting the number of crossovers between homologous chromosomes during meiosis.
    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

    Julene Madariaga-Marcos, Cesar L Pastrana ... Fernando Moreno-Herrero
    A single-molecule biophysical approach reveals that the C-terminal domain of ParB blocks ParB network formation by heterodimerization with the full-length protein, which remains bound to the DNA.
    1. Immunology and Inflammation

    Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

    Magdalena L Russell, Aisha Souquette ... Philip Bradley
    Trans genetic variation in TdT and Artemis loci impacts V(D)J recombination probabilities.

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