776 results found
    1. Cancer Biology
    2. Cell Biology

    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Magda Spella et al.
    Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
    1. Evolutionary Biology

    The Natural History of Model Organisms: Insights into the evolution of social systems and species from baboon studies

    Julia Fischer et al.
    Wild baboons are an excellent model to study complex evolutionary processes such as speciation and hybridization, as well as the links between sociality, longevity and reproductive success.
    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat

    Martin Reichard, Matej Polačik
    The turquoise killifish from ephemeral pools in African savannah combines extremely short lifespan with a standard vertebrate body plan – ideal attributes for a laboratory animal.
    1. Ecology

    The Natural History of Model Organisms: Peromyscus mice as a model for studying natural variation

    Nicole L Bedford, Hopi E Hoekstra
    The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.
    1. Human Biology and Medicine

    Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca et al.
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.
    1. Human Biology and Medicine

    Point of View: Strategies from UW-Madison for rescuing biomedical research in the US

    Judith Kimble et al.
    A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Optical estimation of absolute membrane potential using fluorescence lifetime imaging

    Julia R Lazzari-Dean et al.
    Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

    Carlos Gorbea et al.
    iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.

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