The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain

Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.

Two natural cooling agents activate the cold-activated channel TRPM8 via two opposite mechanisms, evoking distinct electrical responses in cold-sensitive neurons.

Dysfunctions of myelin peroxisomes cause a lysosomal storage-like disorder associated with alterations in glial and axonal membranes, which is the likely cause of nerve impairment in peroxisomal disorders.

In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.

Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.

Specific attachment of molecularly defined gold nanoparticles enables precise localization, critical for structural studies in vivo, of proteins of unknown structure within the cellular milieu by cryo-electron tomography.

Calcium response profiling of large populations of enteric neurons reveals hard-wired neural circuits that reflect the motility program portfolio of the intestinal region they occupy.

Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.

Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.