Smoking is a risk factor for a broad range of gastrointestinal diseases independent of alcohol consumption.

Massive IgG and IgA antibody deposition in severe alcoholic hepatitis livers, targeting unique human proteins and exhibiting hepatocyte killing potential, suggests a role for cross-reactive anti-bacterial antibodies in severe alcoholic hepatitis pathogenesis.

Heavy alcohol drinking primes dynorphin /kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.

Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.

For Drosophila melanogaster, the scent of alcohol—normally associated with preferred egg-laying sites—potentiates a male pheromone signal, thereby increasing the aggressive competition between males for the reproductive resource.

Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.

The gut microbe-derived metabolite trimethylamine (TMA) is elevated in patients with alcohol-associated hepatitis and inhibition of the gut microbial enzymes that produce TMA may serve as a tractable therapeutic strategy for the treatment of ethanol-induced liver injury.

By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

Accounting for the impact of smoking, obesity, and alcohol on past mortality trends, we project, compared to common practice, longer individual lifespans and more elderly in society for the future.

In the orbitofrontal cortex, mTORC1, a multiprotein complex centered around the kinase mTOR, contributes to the development and/or maintenance of habitual alcohol seeking.