141 results found
    1. Epidemiology and Global Health

    Alcohol consumption in the general population is associated with structural changes in multiple organ systems

    Evangelos Evangelou et al.
    The results imply that there is not a safe threshold below which there are no toxic effects of alcohol.
    1. Epidemiology and Global Health

    Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

    Jan Sundquist et al.
    A Swedish national cohort study reveals that children with a family history of alcohol use disorders have an increased risk of autism and attention-deficit/hyperactivity disorder.
    1. Epidemiology and Global Health

    Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor

    Hui Liu et al.
    Smoking, measured by both initiation and intensity, are significantly associated with an elevated expression level of ACE2 in multiple human tissues/organs, subsequently increasing the susceptibility and severity of COVID-19.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

    Jiahui Si et al.
    Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

    Nathalia Luisa Sousa de Oliveira Malacco et al.
    Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
    1. Neuroscience

    Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age

    Simone Kühn et al.
    Trajectories of adolescent drinking behavior between age 14 and 19 years can be predicted from bilateral striatal and cerebellar grey matter at 14 years of age.
    1. Epidemiology and Global Health

    Sense of coherence and risk of breast cancer

    Kejia Hu et al.
    There is little evidence for an association between sense of coherence and risk of breast cancer.
    1. Neuroscience

    Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice

    Lara S Hwa et al.
    Heavy alcohol drinking primes dynorphin /kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.
    1. Developmental Biology
    2. Neuroscience

    The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

    Alexander GJ Skorput et al.
    Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies et al.
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.

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