570 results found
    1. Neuroscience

    TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model

    Sunetra Sase et al.
    H-ABC leukodystrophy results in neurologic decline, hypomyelination and atrophy of the striatum and cerebellum and Tubb4aD249N/D249Nmouse model recapitulates features of H-ABC disease, providing an important tool for therapeutic development.
    1. Structural Biology and Molecular Biophysics

    Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses

    Ling Wang et al.
    The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance energy transfer experiments, which elucidate the rate-limiting mechanism of MRP1's transport cycle.
    1. Cell Biology
    2. Human Biology and Medicine

    Intelligent classification of platelet aggregates by agonist type

    Yuqi Zhou et al.
    An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.
    1. Cancer Biology
    2. Human Biology and Medicine

    Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

    Tim DD Somerville et al.
    A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections

    Morgan A Wambaugh et al.
    Identification and exploitation of interactions between the antifungal drug fluconazole and FDA- approved drugs has the potential to improve treatment for patients with difficult-to-treat systemic fungal infections.
    1. Cancer Biology
    2. Physics of Living Systems

    Collective forces of tumor spheroids in three-dimensional biopolymer networks

    Christoph Mark et al.
    The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.
    1. Physics of Living Systems
    2. Cell Biology

    The axonal actin-spectrin lattice acts as a tension buffering shock absorber

    Sushil Dubey et al.
    A linear array of spectrin tetramers imparts mechanical stability to axons by allowing spectrin domains to unfold reversibly when an axon is stretched, thereby acting as tension buffers.
    1. Biochemistry and Chemical Biology

    Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins

    Joury S van 't Klooster et al.
    Analysis of periprotein lipids by direct extraction of membrane proteins, using styrene-maleic acid polymers.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

    Stephanie C Gantz et al.
    In mouse brain slices, native delta glutamate receptors carry ionic current and underlie the α1-adrenergic receptor-mediated depolarization of dorsal raphe neurons that drives action potential firing in vivo.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

    Friso S Aalbers et al.
    By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

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