A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.

Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.

A detailed characterizations of EDTA-treated Candida albicans cells both in vitro and pre-clinical models led to discovery of a potential live whole-cell vaccine against fungal infections.

Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.

2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.