Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
Pathogenesis in Spinocerebellar Ataxia Type 3 is enhanced by the heat-shock protein family member, Hsc70-4, uncovering new mechanisms of toxicity for this disease and suggesting pleiotropic roles for chaperones.
The double-gene-knockout pig is a valuable model to help understand the mechanisms of CD163 and pAPN in the infection of multiple viruses and offers excellent breeding materials for disease-resistant pigs.
The stdpopsim library, a community-driven open source project, is presented which provides easy access to a standard catalog of published simulation models for population genetics aimed at field-wide standardization.
Structural and computational analyses of germline antibody/HIV-1 gp120 complexes provide both general principles relevant to the unusual evolution of potent CD4-binding site antibodies and guidelines for structure-based immunogen design.