Thibaut Sellinger, Frank Johannes, Aurélien Tellier
The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also specifically inhibits error prone repair of DNA breaks during meiotic prophase I.
Audrey Le Veve, Mathieu Genete ... Vincent Castric
By modulating the intensity of balancing selection at the S-locus, dominance between self-incompatibility alleles shapes the genetic load linked to each allele, creating inbreeding depression in some S-locus homozygotes.
Samuel Pattillo Smith, Gregory Darnell ... Lorin Crawford
Computational analysis reveals that additive summary statistics from genome-wide association studies can provide evidence of non-additive heritability in complex traits.
Analysis of human cytomegalovirus-encoded glycoprotein US10 targeting human leucocyte antigen class I molecules reveals a multimodal strategy, resulting in a geno- and allotypic-dependent effects.
Mathew Thayer, Michael B Heskett ... Phillip A Yates
Molecular genetic analyses of ASARs reveals regulation of large-scale mammalian chromosome structure and function that includes long non-coding RNAs and nuclear RNA binding proteins as essential regulators of chromosome dynamics.
