353 results found
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang et al.
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Immunology and Inflammation

    Epidermal RAF prevents allergic skin disease

    Josipa Raguz et al.
    In keratinocytes, the BRAF and RAF1 proteins work independently to balance the activity of mitogenic and stress kinase cascades and uphold the mechanical and immunological barrier functions of the epidermis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dynamic subcellular localization of a respiratory complex controls bacterial respiration

    François Alberge et al.
    The localization of respiratory complexes in the cell membrane emerges as a critical factor for controlling respiration in bacteria.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

    Donna L Mallery et al.
    The inositol phosphate IP6 is selectively packaged into HIV virions, where it coordinates electropositive pores in the capsid to prevent spontaneous collapse and promote encapsidated DNA synthesis.
    1. Immunology and Inflammation

    Natural Tr1-like cells do not confer long-term tolerogenic memory

    Koshika Yadava et al.
    Natural Tr1-like cells do not form a functionally stable memory response to allergens, and this instability may limit efforts to re-establish tolerance by expanding Tr1.
    1. Cell Biology
    2. Immunology and Inflammation

    Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

    Sara Cipolat et al.
    A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Viruses: The secrets of the stability of the HIV-1 capsid

    Martin Obr, Hans-Georg Kräusslich
    Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.
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  1. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez et al.
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.

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