501 results found
    1. Medicine

    Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

    Guorong Li et al.
    An FDA-approved, rho-associated kinase inhibitor reverses fibrosis in the conventional outflow pathway of a mouse model of glaucoma and reverses ocular hypertension in patients with steroid glaucoma.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

    Nandish Khanra et al.
    Structures of the GluK2/K5 kainate receptor reveal the heteromer architecture and how the receptor organizes in apo, antagonist-bound, and desensitized states.
    1. Medicine

    Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

    Wanxia Gai et al.
    Epigenetic determination of tissue of origin of genetically classified subsets of plasma DNA molecules enhances transplantation monitoring and cancer testing.
    1. Immunology and Inflammation
    2. Medicine

    Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

    Ada Weinstock et al.
    Wnt signaling is revealed to be a regulator of macrophage inflammation-resolving state in atherosclerosis through a PGE2-mediated pathway.
    1. Genetics and Genomics
    2. Neuroscience

    Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

    Cesar P Canales et al.
    Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith et al.
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.
    1. Structural Biology and Molecular Biophysics

    Single-molecule view of coordination in a multi-functional DNA polymerase

    Raymond F Pauszek III et al.
    The primer extension and 5' flap processing activities of DNA polymerase I are physically coordinated by combined movements of the DNA substrate and the 5' nuclease domain of the enzyme.
    1. Cell Biology
    2. Immunology and Inflammation

    Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

    Leonie Zeitler et al.
    IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.

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