38 results found
    1. Neuroscience

    Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain

    Romain Cardis et al.
    Neuropathic pain preserves mouse sleep in architecture and characteristic spectral bands but perturbs arousability in ways reminiscent of insomnia disorders, in which hyperarousal and hyperalertness to environmental stimuli are prevalent.
    1. Neuroscience

    Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

    Line S Löken et al.
    Although primary sensory neuron-derived calcitonin gene-related peptide (CGRP) contributes to the processing of pain messages, an understudied population of dorsal horn CGRP-expressing interneurons also contributes to the processing of mechanical sensitivity.
    1. Genetics and Genomics
    2. Medicine

    Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

    Matthew William Grol et al.
    Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei et al.
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Neuroscience

    Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

    Zachariah Bertels et al.
    In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
    1. Medicine

    Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

    Qi Sun et al.
    Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.
    1. Neuroscience

    A spinoparabrachial circuit defined by Tacr1 expression drives pain

    Arnab Barik et al.
    A circuit involving Tacr1-expressing neurons in the spinal cord and the parabrachial nucleus controls how mice respond to a wide range of persistently painful stimuli.
    1. Neuroscience

    Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

    Robert AR Drake et al.
    Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.
    1. Neuroscience

    Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

    Sven Dannhäuser et al.
    An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.
    1. Neuroscience

    Upregulation of TRPM3 in nociceptors innervating inflamed tissue

    Marie Mulier et al.
    The expression and function of the cation channel TRPM3 is strongly increased in sensory neurons innervating inflamed tissue, likely contributing to inflammatory hyperalgesia and persistent pain.

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