479 results found
    1. Structural Biology and Molecular Biophysics

    Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

    Georg Kuenze et al.
    An integrative structural biology approach provides refined models of the KCNQ1-KCNE1 channel complex, which propose a new mechanism to explain how KCNE1 modulates KCNQ1 channel activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

    Daiana A Capdevila et al.
    Internal dynamics play a crucial functional role in MarR (multiple antibiotic resistance repressor) proteins and their role reconciles the distinct allosteric mechanisms proposed previously.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The allosteric activation of cGAS underpins its dynamic signaling landscape

    Richard M Hooy, Jungsan Sohn
    Rigorous biophysical studies reconcile several conflicting views on how cGAS is activated, and present a new unifying allosteric activation mechanism.
    1. Structural Biology and Molecular Biophysics

    Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

    Jingjing Guo, Huan-Xiang Zhou
    Simulations of molecular dynamics suggest how the binding of the β-grasp domain of SUMO1 induces conformational and dynamic effects to activate SENP1.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The dual role of chloride in synaptic vesicle glutamate transport

    Roger Chang et al.
    Whole endosome recording shows that chloride interacts with vesicular glutamate transporters as both allosteric activator and permeant ion, and although the mode of permeation differs, chloride and glutamate use a related conduction pathway.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

    Jamie A Macpherson et al.
    Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

    Feng Zhang et al.
    TRPV channels share general mechanisms of activation while exhibiting subtype-specific features along the activation pathway that can determine their apparent sensitivity to stimuli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

    Adelajda Zorba et al.
    Aurora A kinase, an anti-cancer drug target, can be activated by two independent mechanisms.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

    Emily F Ruff et al.
    Phosphorylation of Aurora A does not trigger a population shift to the active state as previously thought, but instead switches the kinase on by tuning the structure and dynamics of a dynamically sampled subpopulation.
    1. Biochemistry and Chemical Biology

    Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

    Benjamin G Horst et al.
    The full-length structures of the mammalian nitric oxide receptor reveal the molecular activation steps and a binding site for the prototype of FDA-approved stimulators.

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