Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.

Native mass spectrometry reveals the thermodynamic basis for high-affinity lipid binding to the ABC transporter MsbA.

Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.

Docosahexaenoic acid (DHA) inhibits ELIC through state-dependent binding to a single site.

The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).

Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.

Blocking of the function of neurotransmitter receptors by insecticidal peptide toxins resulted in identification of nicotinic acetylcholine receptor subunits through native ligand-binding investigations.

Ded1p and eIF4A, two RNA helicases that function in eukaryotic translation initiation, interact physically with each other and with the scaffolding protein eIF4G.

Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.

Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.