63 results found
    1. Biochemistry and Chemical Biology

    Mechano-redox control of integrin de-adhesion

    Freda Passam et al.
    Ligand binding, force and chemistry combine to control the function of a cell surface receptor.
    1. Structural Biology and Molecular Biophysics

    Structural Biology: NMR illuminates the pathways to ALS

    Tao Xie, Charalampos G Kalodimos
    Insight
    Available as:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

    William John Allen et al.
    Evidence is presented that supports a completely new, diffusion-driven mechanism for transporting proteins across membranes in bacteria.
    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

    Jonathan M Wagner et al.
    Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagellar capping proteins adopt diverse oligomeric states

    Sandra Postel et al.
    The first high-resolution structure of a bacterial flagellar cap protein, FliD, reveals new insights into the assembly of bacterial flagella.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Super Spy variants implicate flexibility in chaperone action

    Shu Quan et al.
    Lab-evolved 'super Spy' chaperones show enhanced flexibility, which allows them to bind to and stabilize proteins more effectively than natural chaperones.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

    Sandeep K Talapatra et al.
    Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.

Refine your results by:

Type
Research categories