Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.

Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.

The functional differences between actin isoforms have been explored through structural studies.

RNA polymerase recruits the PcrA DNA helicase via a conserved interaction motif in order to remove R-loops and prevent conflicts with replication.

Mitochondrial respiratory chain dysfunction inhibits mitochondrial one-carbon metabolism, impairing cellular nucleotide biosynthesis.

Solution NMR spectroscopy reveals the energy landscape of immature Cu, Zn-superoxide dismutase and leads to atomic resolution structural models of transiently populated non-native oligomers.

Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.

Structures of the human ataxia-telangiectasia mutated (ATM) kinase alone and bound to the C-terminus of Nbs1 show the mechanisms underlying ATM autoinhibition and binding by a portion of the Mre11-Rad50-Nbs1 (MRN) activating complex.

The resurrection of ancient ancestral intrinsically disordered proteins reveals the evolution of a protein-protein interaction in molecular detail.

Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.