409 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra et al.
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system

    Joseph Crispell et al.
    Analyses combining genomic and epidemiological data of Mycobacterium bovis, which causes bovine tuberculosis, revealed evidence of transmission within and between cattle and badger populations.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons et al.
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz et al.
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

    Elisabeth A Geyer et al.
    A buried mutation in αβ-tubulin reveals an allosteric response to GDP in the lattice that dictates microtubule catastrophe and shrinking.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics

    Stanley Nithianantham et al.
    Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Cell Biology
    2. Developmental Biology

    LINKIN, a new transmembrane protein necessary for cell adhesion

    Mihoko Kato et al.
    LINKIN and three of its interactors-RUVBL1, RUVBL2, and α-tubulin-are required for cells to migrate together during organogenesis.

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