193 results found
    1. Cell Biology
    2. Neuroscience

    A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    Sonal Nagarkar-Jaiswal et al.
    A large collection of functional EGFP tagged proteins derived from MiMIC insertions allows examination of protein expression in unfixed tissues and efficient tissue specific reversible knock down of proteins.
    1. Biochemistry and Chemical Biology

    Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

    Marta Carroni et al.
    Head-to-head interactions of regulatory coiled-coil domains control activity of the central bacterial AAA+ protein ClpC by promoting formation of a reversible resting state.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei et al.
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho et al.
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
    1. Immunology and Inflammation

    α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

    Oliver Gordon et al.
    The Drosophila response to injection of alpha-actinin reinforces the notion that exposure of cytoskeletal components acts as a sign of cell damage conserved throughout metazoan evolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy

    Kien Xuan Ngo et al.
    A cluster of cofilin along an otherwise bare actin filament induces distinctively asymmetric cooperative conformational changes to the filament on either side of the cluster.
    1. Cell Biology
    2. Computational and Systems Biology

    Signaling pathways as linear transmitters

    Harry Nunns, Lea Goentoro
    Mathematical and experimental analyses suggest that despite their complex architectures, multiple metazoan signaling pathways act in physiological contexts as linear signal transmitters.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith et al.
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans

    Chaolie Huang et al.
    Age-dependent protein aggregation closely resembles protein aggregation associated with neurodegenerative diseases and other amyloidoses, and initiates early functional decline in different tissues.

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