19 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen et al.
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.
    1. Chromosomes and Gene Expression

    Viral-induced alternative splicing of host genes promotes influenza replication

    Matthew G Thompson et al.
    Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

    Kazi Rahman et al.
    A disease-associated polymorphism in a related protein that regulates neurotransmitter release reveals that antiviral protein IFITM3 forms oligomers to rigidify membranes and inhibit virus fusion with cells.
    1. Microbiology and Infectious Disease

    Lipid hijacking: A unifying theme in vector-borne diseases

    Anya J O'Neal et al.
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Microbiology and Infectious Disease

    Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

    Kathryn S Carpentier et al.
    The scavenger receptor MARCO and liver phagocytes are required for clearance of circulating alphavirus particles and thereby limit viremia and viral dissemination.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

    Michel Tassetto et al.
    Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.
    1. Microbiology and Infectious Disease

    Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

    Myra Hosmillo et al.
    A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

    Mattia Ficarelli et al.
    KHNYN, a putative endoribonuclease, interacts with the zinc-finger antiviral protein (ZAP) and is required for the inhibition of HIV replication and RNA abundance by CpG dinucleotides.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface

    Eduardo A Bignon et al.
    Hantavirus spikes are related laterally by 2-fold Gc contacts that can be disulfide-linked and display a temperature-dependent dynamic behavior at neutral pH, exposing and masking the Gc fusion loops.

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