19 results found
    1. Microbiology and Infectious Disease

    Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

    Kathryn S Carpentier et al.
    The scavenger receptor MARCO and liver phagocytes are required for clearance of circulating alphavirus particles and thereby limit viremia and viral dissemination.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

    Mattia Ficarelli et al.
    KHNYN, a putative endoribonuclease, interacts with the zinc-finger antiviral protein (ZAP) and is required for the inhibition of HIV replication and RNA abundance by CpG dinucleotides.
    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle et al.
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

    Ruben Soto-Acosta et al.
    The Zika virus subgenomic flaviviral RNA binds to and inhibits the fragile X mental retardation protein, a novel Zika virus restriction factor.
    1. Microbiology and Infectious Disease

    Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

    Matthew D Daugherty et al.
    Evolutionary innovation and turnover in the IFIT1 antiviral gene family has led to diverse repertoires of antiviral specificity across mammals.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface

    Eduardo A Bignon et al.
    Hantavirus spikes are related laterally by 2-fold Gc contacts that can be disulfide-linked and display a temperature-dependent dynamic behavior at neutral pH, exposing and masking the Gc fusion loops.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Comparative analysis of viral RNA signatures on different RIG-I-like receptors

    Raul Y Sanchez David et al.
    An experimental approach allowing characterization of viral RNA ligands recognized by RIG-I-like receptors during infection by any RNA viruses is established and validated.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Chromosomes and Gene Expression

    Viral-induced alternative splicing of host genes promotes influenza replication

    Matthew G Thompson et al.
    Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
    1. Microbiology and Infectious Disease

    Lipid hijacking: A unifying theme in vector-borne diseases

    Anya J O'Neal et al.
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.

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