5,314 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush et al.
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Chromosomes and Gene Expression

    Viral-induced alternative splicing of host genes promotes influenza replication

    Matthew G Thompson et al.
    Infection of human cells by influenza A virus induces changes in the alternative splicing of host genes that, in turn, promote viral replication.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia et al.
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Neuroscience

    CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

    Lizhen Chen et al.
    Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku et al.
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf et al.
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2

    Elektra K Robinson et al.
    Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

    Yoseop Yoon et al.
    Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.

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