179 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective

    Joseph Ackermann, Chiara Bernard ... Martine Ben Amar
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen

    Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
    In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
    1. Cell Biology

    Atlas of Fshr expression from novel reporter mice

    Hongqian Chen, Hui-Qing Fang ... Peng Liu
    Exploiting the power of the Fshr reporter, the first comprehensive genetic record of the spatial distribution of FSHR expression offers prospects for extensive exploration of FSH-FSHR biology.
    1. Microbiology and Infectious Disease

    Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

    Nelson V Simwela, Eleni Jaecklein ... David G Russell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism

    Hong Huang, Ying Yang ... Le Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

    Donal J Cox, Sarah A Connolly ... Joseph Keane
    The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory medicine.
    1. Microbiology and Infectious Disease

    Telomerase RNA component knockout exacerbates Staphylococcus aureus pneumonia by extensive inflammation and dysfunction of T cells

    Yasmina Reisser, Franziska Hornung ... Stefanie Deinhardt-Emmer
    Knockout of Terc impedes effective immune defense against bacterial lung infections in mice, exacerbating disease course and revealing the critical function of Terc in pulmonary immunity.
    1. Microbiology and Infectious Disease

    Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

    Mariëtta M Ravesloot-Chávez, Erik Van Dis ... Sarah A Stanley
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Medicine
    2. Immunology and Inflammation

    Inhibition on neutrophil extracellular traps by oligomeric procyanidins alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

    Yaqi Luan, Weiwei He ... Rong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

    Nayoung Kim, Sehhoon Park ... Myung-Ju Ahn
    Single-cell RNA sequencing of biopsy samples from advanced-stage lung cancer reveals tumor and immune cell features associated with response to immune checkpoint therapy.
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