458 results found
    1. Medicine

    Science Forum: Improving preclinical studies through replications

    Natascha Ingrid Drude et al.
    Increasing validity should be a priority when deciding which preclinical experiments to replicate and when performing replications.
    1. Neuroscience

    Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline

    Quanjing Chen et al.
    Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky et al.
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Genetics and Genomics
    2. Neuroscience

    A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

    François Kroll et al.
    Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.
    1. Neuroscience

    Correlating STED and synchrotron XRF nano-imaging unveils cosegregation of metals and cytoskeleton proteins in dendrites

    Florelle Domart et al.
    The development of high-resolution correlative imaging of metals and proteins reveals the interaction of copper and zinc with the synaptic architecture of neurons.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Therapeutic genetic variation revealed in diverse Hsp104 homologs

    Zachary M March et al.
    Exploring natural Hsp104 variation reveals unexpected tuning of a passive activity that inhibits aggregation of specific substrates to selectively counter TDP-43 or alpha-synuclein proteotoxicity connected to neurodegenerative disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

    Jone Paesmans et al.
    Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy et al.
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Cell Biology
    2. Neuroscience

    TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

    Kathleen M Cunningham et al.
    Impaired nuclear import of the transcription factor TFEB/MITF is a major cause of autophagy and lysosome dysfunction in amyotrophic lateral sclerosis caused by mutations in the C9orf72 gene.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.

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