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    1. Neuroscience

    Stimulus-dependent recruitment of lateral inhibition underlies retinal direction selectivity

    Qiang Chen et al.
    Synapse-specific genetic manipulations show that distinct GABAergic inputs are differentially recruited to encode motion direction in the retina in a stimulus-dependent manner.
    1. Cell Biology
    2. Ecology

    Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes

    Sebastien Colin et al.
    Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.
    1. Developmental Biology
    2. Neuroscience

    Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function

    Dimitar Kostadinov, Joshua R Sanes
    Patterning of dendrites by protocadherin-dependent self-avoidance and self/non-self discrimination is required for proper function of a retinal circuit that computes the direction of motion.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina

    Jasper J Visser et al.
    An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
    1. Neuroscience

    Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

    Shinji Urata et al.
    A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Ecology
    2. Microbiology and Infectious Disease

    Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics

    Simon Roux et al.
    Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
    1. Plant Biology

    Automated quantitative histology reveals vascular morphodynamics during Arabidopsis hypocotyl secondary growth

    Martial Sankar et al.
    Combining high-resolution imaging with automated image segmentation and supervised machine learning achieves accurate cellular feature extraction and automated cell type recognition in a large-scale developmental process.
    1. Cell Biology
    2. Physics of Living Systems

    KymoButler, a deep learning software for automated kymograph analysis

    Maximilian AH Jakobs et al.
    KymoButler is a machine learning approach towards the reliable, quick, and fully automated analysis of the dynamics of fluorescently labelled particles in living cells.