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1,573 results found
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

    Saumel Ahmadi et al.
    Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov et al.
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Immunology and Inflammation

    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

    Julia M Marchingo et al.
    Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni et al.
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe et al.
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters

    Mary Hongying Cheng et al.
    Novel evidence on the molecular determinants of the dual function, anion permeation and substrate transport, of excitatory amino acid transporters opens avenues toward illuminating how these transporters regulate synaptic function and contribute to neurological conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Consensus designs and thermal stability determinants of a human glutamate transporter

    Erica Cirri et al.
    A fast evolutionary approach to engineer membrane protein kinetic stability yields folded excitatory neurotransmitter transporters and provides insights into their denaturing pathway.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba et al.
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acquisition of exogenous haem is essential for tick reproduction

    Jan Perner et al.
    The lack of haem biosynthetic and degradative pathways in ticks offers new strategies to combat these parasites.

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