317 results found
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni et al.
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.
    1. Cell Biology

    In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

    Angelica Aguilera-Gomez et al.
    Amino-acid induced Sec body formation is mediated by PARP16 dependent MARylation of Sec16, a component of the endoplasmic reticulum exit site.
    1. Cell Biology
    2. Genetics and Genomics

    The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

    Heather P Harding et al.
    Genetic lesions that compromise the ribosome P-stalk implicate direct signalling from the ribosome to the translation initiation factor eIF2 kinase GCN2 in the cellular response to amino acid starvation.
    1. Computational and Systems Biology

    Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

    Michael A Ferrin, Arvind R Subramaniam
    Collision between ribosomes can cause dissociation of stalled ribosomes from messenger RNAs during the process of mRNA translation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Brain Size: Gene losses did not stop the evolution of big brains

    Cristian Cañestro, Vittoria Roncalli
    Elephants and fruit bats have evolved large brains even though they have lost a gene that is fundamental to the supply of energy to the brain when glucose is not available.
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    1. Cell Biology

    Autophagy: COPII vesicles and the expansion of the phagophore

    Catherine Rabouille
    A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.
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    1. Biochemistry and Chemical Biology

    Gene Regulation: Acting in tandem

    Robert A Battaglia, Ailong Ke
    RNA structures called tandem riboswitches allow bacteria to employ complex logical operations in response to nutrient starvation.
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    1. Cell Biology
    2. Human Biology and Medicine

    Cancer Metabolism: Partners in the Warburg effect

    Joshua D Rabinowitz, Hilary A Coller
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    1. Genetics and Genomics

    Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

    Yue Zhang et al.
    Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.

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