612 results found
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock, Danitra Parker ... Kasturi Mitra
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
    1. Neuroscience

    Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep

    Anish Mitra, Abraham Z Snyder ... Marcus E Raichle
    Human fMRI experiments reveal differences in the propagation of spontaneous brain activity during sleep versus wakefulness.
    1. Ecology

    An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

    Lei Guo, Xin-yu Fan ... Jia Huang
    The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.
    1. Genetics and Genomics

    Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila

    Iryna Shakhmantsir, Soumyashant Nayak ... Amita Sehgal
    Alternative splicing provides a mechanism to maintain oscillations of the circadian clock.
    1. Cell Biology
    2. Medicine

    MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

    Shilpak Bele, Shravan Babu Girada ... Prasenjit Mitra
    Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin, Yeonsook Shin Takahashi ... Partha Mitra
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Neuroscience
    2. Genetics and Genomics

    Ecdysone acts through cortex glia to regulate sleep in Drosophila

    Yongjun Li, Paula Haynes ... Amita Sehgal
    Effects of ecdysone on sleep are mediated through lipid metabolism in cortex glia.
    1. Computational and Systems Biology

    Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs

    Ramkrishna Mitra, Clare M Adams, Christine M Eischen
    The discovery of uncharacterized lncRNAs that regulate cell proliferation/growth across cancer types, including two p53 regulated tumor suppressive lncRNAs, were identified through systematic analyses of multi-omics data and provides a computational framework resource to cancer researchers.
    1. Genetics and Genomics
    2. Neuroscience

    Orai-mediated calcium entry determines activity of central dopaminergic neurons by regulation of gene expression

    Rishav Mitra, Shlesha Richhariya, Gaiti Hasan
    Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.
    1. Neuroscience

    Modulation of RNA processing genes during sleep-dependent memory

    Yongjun Li, Nitin S Chouhan ... Amita Sehgal
    RNA processing genes regulated during sleep-dependent memory may contribute to sleep and memory.

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