424 results found
    1. Biochemistry and Chemical Biology

    A two-lane mechanism for selective biological ammonium transport

    Gordon Williamson et al.
    A new cellular transport mechanism splits the substrate and separately translocates its fragments to achieve selectivity.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-fluorophore membrane transport activity sensors with dual-emission read-out

    Cindy Ast et al.
    Building on previous work (De Michele et al., 2013), we report the development of dual-emission AmTrac sensors for in vivo analysis of transporter activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters

    Cheng-Hsun Ho, Wolf B Frommer
    Peptide and nitrate transporters have been converted into fluorescent reporters of transport activity and have been used to measure various transport properties including the dual affinity of the nitrate transceptor
    1. Plant Biology

    Transport Proteins: Getting to grips with ammonium

    Yi Wang, Jonathan A Javitch
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    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Genetics and Genomics

    An incoherent feedforward loop facilitates adaptive tuning of gene expression

    Jungeui Hong et al.
    The architecture of a gene regulatory network determines the effect of evolutionary changes in transcription factor binding.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov et al.
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Cancer Biology

    A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

    Haojie Jin et al.
    Combination of glutaminase inhibitor CB-839 and ASCT2 inhibitor V-9302 showed efficient antitumor effect against glutamine addicted liver cancer cells via glutathione depletion and reactive oxygen species (ROS) induction.
    1. Biochemistry and Chemical Biology

    Ammonium Transporters: A molecular dual carriageway

    William J Allen, Ian Collinson
    In order to enter a cell, an ammonium ion must first dissociate to form an ammonia molecule and a hydrogen ion (a proton), which then pass through the cell membrane separately and recombine inside.
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