54 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

    Olivier Cochet-Escartin et al.
    Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
    1. Cell Biology

    VASP-mediated actin dynamics activate and recruit a filopodia myosin

    Ashley L Arthur et al.
    Filopodia formation requires recruitment and activation of myosin through generation of parallel, bundled actin filaments by VASP polymerase, revealing coupling between motor activation and organization of a local actin network.
    1. Neuroscience

    The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo

    Monique S Mendes et al.
    Adult microglia are born by the division of single surviving microglia that rapidly acquire mature morphologies and functions in order to perform their physiological roles in the brain.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston et al.
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Cell Biology

    A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

    Elizabeth M Steenkiste et al.
    Epithelial cells coordinate integrin signaling with protrusion via a two-protein module, with one protein defining localization and downstream signaling, the other serving as a phosphorylation switch and providing negative feedback.
    1. Cell Biology

    ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

    Maria F Ullo, Jeremy S Logue
    Fast amoeboid migrating cells require both cofilin-1 and ADF for fast actin turnover at 'leader bleb' necks.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Membrane binding controls ordered self-assembly of animal septins

    Agata Szuba et al.
    Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
    1. Immunology and Inflammation
    2. Neuroscience

    Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    Alessio Vittorio Colombo et al.
    Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.

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