4 results found
    1. Medicine
    2. Neuroscience

    Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

    Shenhab Zaig, Carolina da Silveira Scarpellini, Gaspard Montandon
    Emerging approaches in larval zebrafish to identify safe opioid therapies without the side-effect of respiratory depression.
    1. Cell Biology
    2. Developmental Biology

    Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

    Keiichiro Koiwai, Takashi Koyama ... Ryuji Kawano
    Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.
    1. Neuroscience

    Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

    Nathan A Baertsch, Nicholas E Bush ... Jan-Marino Ramirez
    Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.
    1. Medicine
    2. Neuroscience

    Acute ampakines increase voiding function and coordination in a rat model of SCI

    Sabhya Rana, Firoj Alom ... Aaron D Mickle
    Ampakines demonstrate efficacy in enhancing bladder function in animal models of spinal cord injury, presenting promising prospects for innovative pharmacotherapy to alleviate post-injury bladder dysfunction.

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