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    1. Neuroscience

    Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

    Ioannis Zalachoras, Eva Ramos-Fernández ... Carmen Sandi
    The capacity to sustain effort to obtain rewards over time depends on the levels of the antioxidant glutathione in the nucleus accumbens - a brain region critical for motivated behavior - and can be boosted with a nutritional intervention (N-acetylcysteine).
    1. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos, Aylesse Sordillo ... Jeffrey M Friedman
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
    1. Computational and Systems Biology
    2. Ecology

    Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels

    Xin Li, Vivian Yaci Yu ... Jamie HD Cate
    Parallel pathways of xylose metabolism identified in fungi that grow on plants can be used in yeast to promote hemicellulose conversion to biofuels.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Recreating the synthesis of starch granules in yeast

    Barbara Pfister, Antoni Sánchez-Ferrer ... Samuel C Zeeman
    Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.
    1. Medicine

    VO2max prediction based on submaximal cardiorespiratory relationships and body composition in male runners and cyclists: a population study

    Szczepan Wiecha, Przemysław Seweryn Kasiak ... Andrzej Klusiewicz
    VO2max in endurance athletes can be accurately predicted by the submaximal cardiopulmonary exercise testing measurements but relying solely on somatic variables allows limited accuracy, which is especially important for physicians and fitness practitioners for proper health and training status monitoring.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism

    Sara Tejedor-Sanz, Eric T Stevens ... Maria L Marco
    Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.
    1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama
    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.
    1. Neuroscience

    RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

    Brooks G Robinson, Xintong Cai ... Pascal S Kaeser
    Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

    Kai Xie, Naixiang Wang ... Peng Shi
    An implantable device based on organic electrochemical transistors is developed for quantitative mapping of neurotransmitter release across multiple brain regions, revealing a cross-talk between the mesolimbic and nigrostriatal dopaminergic pathways.
    1. Evolutionary Biology

    Colour polymorphism associated with a gene duplication in male wood tiger moths

    Melanie N Brien, Anna Orteu ... Johanna Mappes
    A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.