189 results found
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipitò ... Christopher A Reynolds
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Role of the αC-β4 loop in protein kinase structure and dynamics

    Jian Wu, Nisha A Jonniya ... Susan S Taylor
    The importance of the αC-β4 loop at the interface between the N- and C-lobes of Protein Kinase A for synergistic high-affinity binding of ATP and a pseudo substrate inhibitor.
    1. Microbiology and Infectious Disease

    Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

    Li Zhang, Fen Hu ... Hang Yang
    A new peptidoglycan hydrolase mined from Acinetobacter baumannii proteome by lysin-derived antimicrobial peptide-primed screening strategy undergoes a unique switch between dimer and monomer after heat treatment and protects mice from A. baumannii infection.
    1. Neuroscience

    Key determinants of the dual clamp/activator function of Complexin

    Mazen Makke, Alejandro Pastor-Ruiz ... Dieter Bruns
    The amphipathic helix at the C-terminus of Complexin II prevents premature secretion, whereas its N-terminal domain regulates mechanisms which are governed by the forward rate of Ca2+ binding to Synaptotagmin I.
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny H Nguyen ... Thomas C Boothby
    The ability of intrinsically disordered proteins to protect sensitive enzymes during drying can be tuned through interactions with cosolutes.
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Membrane binding properties of the cytoskeletal protein bactofilin

    Ying Liu, Rajani Karmakar ... Martin Thanbichler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistance

    Jeongsik Kim, Dahyun Kim ... Dae-Sik Lim
    Formation of a giant unilocular vacuole through a macropinocytosis-like process in cells with disrupted actin cytoskeleton promotes resistance to anoikis.
    1. Chromosomes and Gene Expression

    A comparative study of the cryo-EM structures of Saccharomyces cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

    Ester Vazquez-Fernandez, Jing Yang ... David Barford
    The yeast APC/C cryo-EM structure reveals substantial similarities with the human APC/C structure but also important differences in mechanisms of phosphorylation-dependent regulation and activation by coactivators.

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