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Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.

Disposal of ciliary proteins via ectosomes budding from cilia tip or cilia base acts as a safeguard mechanism when cilia trafficking functions are impaired.

A combination of state-of-the-art biochemical, biophysical, and computational methods revealed that water molecules play a central role in signal propagation through G protein-coupled receptors.

The structures of plant CIII2, CIV, and SC III2+IV challenge long-standing assumptions, generate new mechanistic hypotheses and allow for the generation of more selective agricultural inhibitors.

Cryo-EM structures reveal how the canonical TRPC4 cation channel is regulated by calmodulin, and how it is modulated by pyridazinone-based inhibitors.

Structure of the Ca²⁺ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca²⁺ entry into immune and other non-excitable cells.

Structures of multiple states of two dicarboxylate transporters explain the conformational changes needed for substrate import.

A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.

The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.

Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.