403 results found
    1. Neuroscience

    Dynamic dichotomy of accumbal population activity underlies cocaine sensitization

    Ruud van Zessen et al.
    Cocaine elicits opposing activity changes in D1R vs D2R spiny projection neurons of the nucleus accumbens with much variability, subsequent recruitment of a subset of D1R neurons drives behavioral sensitization.
    1. Neuroscience

    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

    Jormay Lim et al.
    Mouse brain neurons response to transcranial ultrasound at the energy level of 5 mW/cm2 and repeated stimulations lead to neurogenesis while ASIC1a is required both in vitro and in vivo as one of the mechanoreceptors.
    1. Neuroscience

    ‘Fearful-place’ coding in the amygdala-hippocampal network

    Mi-Seon Kong et al.
    By recording simultaneous spike trains from fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons in rats foraging for food in a risky predatory situation, a novel BA-dHPC circuit coding mechanism for interfacing danger and place information was revealed.
    1. Neuroscience

    A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

    Sharon R Ladyman et al.
    Despite voluntary exercise being rewarding to mice, pregnancy hormones act in the maternal brain to markedly reduce the time females choose to engage in this activity.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang et al.
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
    1. Neuroscience

    Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

    Anita E Autry et al.
    Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
    1. Neuroscience

    The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

    Casey Paquola et al.
    The BigBrainWarp toolbox facilitates integration of 3D human brain histology with neuroimaging, helping neuroscientists to utilise cytoarchitectural information in conjunction with in vivo imaging.
    1. Neuroscience

    L-DOPA modulates activity in the vmPFC, nucleus accumbens, and VTA during threat extinction learning in humans

    Roland Esser et al.
    Encoding an expected, but absent, threat is modulated by dopaminergic neurotransmission that regulates success of extinction learning in humans.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.

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