815 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations

    Mireia Seuma et al.
    A massively parallel analysis of the effects of mutations on amyloid beta nucleation provide the first comprehensive atlas of how mutations alter the formation of amyloid fibrils.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

    Mehabaw G Derebe et al.
    Serum amyloid A proteins bind retinol with nanomolar affinity, and do so by forming oligomers that create a hydrophobic pocket that shields retinol from the aqueous environment.
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

    Ana Filipa Domingues et al.
    Histone acetyl-transferase Kat2a preserves leukemia stem cells through frequent transcriptional firing of metabolic and regulatory gene promoters and maintenance of a largely invariant self-renewal program.
    1. Structural Biology and Molecular Biophysics

    Structural mapping of oligomeric intermediates in an amyloid assembly pathway

    Theodoros K Karamanos et al.
    Solution NMR provides structural and kinetic information about oligomers on pathway to amyloid fibrils that are precisely structured but not cytotoxic.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

    Boris Brumshtein et al.
    Ligands that bind dimers of light chain variable domains inhibit the formation of amyloid fibrils.
    1. Neuroscience

    Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline

    Stephanie L Leal et al.
    Cognitively normal older adults show a positive relationship between neural activity during memory encoding and brain β-amyloid deposition rate over the subsequent 3-4 years, supporting preclinical data that associates neural activity with β-amyloid deposition.
    1. Cancer Biology

    Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

    Yaqing Zhang et al.
    In the pancreas, reciprocal interactions between epithelial cells and myeloid cells determine the balance between tissue repair and carcinogenesis by regulating acinar cell plasticity through differential activation of EGFR/MAPK signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular tweezer antagonizes seminal amyloids and HIV infection

    Edina Lump et al.
    CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.
    1. Structural Biology and Molecular Biophysics

    Semen amyloids participate in spermatozoa selection and clearance

    Nadia R Roan et al.
    Ex vivo characterization of the interaction of human sperm with semen factors reveals that semen amyloids, previously discovered due to their ability to enhance HIV infection, serve a physiological function by promoting disposal of the defective sperm.

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