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    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Recording γ-secretase activity in living mouse brains

    Steven S Hou, Yuya Ikegawa ... Masato Maesako
    A new imaging tool to record γ-secretase activity in vivo.
    1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi
    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

    Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik
    Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
    1. Neuroscience

    APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ

    Mengxun Luo, Jia Zhou ... Yelin Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

    Lukas Frey, Dhiman Ghosh ... Jason Greenwald
    The amyloid polymorph selection that occurs during α-synuclein aggregation is dictated by environmental conditions, in particular pH, with the largest variety of structures being observed near neutral pH.
    1. Neuroscience

    The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

    Weiwei Qi, Yanlan Long ... Guoquan Gao
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
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