213 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

    David M Bolduc et al.
    The protease γ-secretase generates amyloid-beta peptides using a mechanism that is driven by the stabilization of an enzyme-substrate scisson complex.
    1. Neuroscience

    Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

    Emelyne Teo et al.
    Metabolic defects following expression of Aβ1-42 in nematode neurons are partially caused by inactivation of alpha-ketoglutarate dehydrogenase and can be rescued by Metformin.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure-based inhibitors of amyloid beta core suggest a common interface with tau

    Sarah L Griner et al.
    Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.
    1. Human Biology and Medicine
    2. Neuroscience

    Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

    Jerome Robert et al.
    Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

    Lin Jiang et al.
    By using structural methods to screen compounds for their ability to interact with amyloid beta, researchers have identified small molecules that stabilize amyloid fibers and reduce the toxic effect of smaller aggregates on cells.
    1. Neuroscience

    LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

    Daniela Puzzo et al.
    Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
    1. Cell Biology
    2. Neuroscience

    FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

    Tae-In Kam et al.
    By binding to Fc gamma receptor IIb, amyloid beta induces a series of phosphorylation events that mediate the damaging effects of hyperphosphorylated tau proteins in Alzheimer's disease.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.

Refine your results by:

Type
Research categories