148 results found
    1. Biochemistry and Chemical Biology

    Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration

    Cong Chen, Tong-Yao Gao ... Wei-Ping Zhang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity

    Anjali Bisht, Srikanth Pippadpally ... Vimlesh Kumar
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Cell Biology

    Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

    John Yong, Jacqueline E Villalta ... Calvin H Jan
    Genome-wide CRISPRi screens and proteome profiling of lysosomes link lipid dysregulation to ESCRT disruption and proteostasis defect.
    1. Neuroscience

    A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

    Hyo Jun Kwon, Devi Santhosh, Zhen Huang
    Molecular genetics identifies a novel microglial pathway essential for mouse brain development and a previously unknown anti-inflammatory activity of monomeric amyloid β that activates this pathway.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conformational fingerprint for amyloidogenic light chains

    Cristina Paissoni, Sarita Puri ... Carlo Camilloni
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses

    Irene Martínez-Gallego, Heriberto Coatl-Cuaya, Antonio Rodriguez-Moreno
    Two different forms of brain plasticity require astrocytes and show different action mechanisms at enthorrinal cortex hippocampal synapses.
    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Esther Park ... Michel Bagnat
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Elucidating ATP’s role as solubilizer of biomolecular aggregate

    Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
    ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    The flexible stalk domain of sTREM2 modulates its interactions with phospholipids in the brain

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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